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Cake day: January 24th, 2024

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  • Aside from some comments mentioning how immune reset therapies are in fact a thing through either antibody or chemical depletion of your immune cells. These can show improvement but it is very far from curative and not too much better chances than existing immune suppression stuff.

    The danger to an immune “reset” are that you are generally then able to be reinfected with every cold and flu as well. This is dangerous for older or already fragile people. The existing therapies reduce this danger by not entirely wiping memory cells out but that also means they aren’t always curative.

    Beyond that autoimmune diseases in general are a mix of genetics and environmental factors (and even gut bacteria by some studies). If the underlying problem isn’t fixed then relapse is a question of when not if. It’s like adding fluid to a container with a leak, eventually you’re going to have to add more again unless you fix the leak first.

    So we have to find where the “leaks” are, what they are caused by and fix the cause(s) to have something that is an actual cure. Right now we mostly know where the leaks are and some causes and can patch some up leaks up. However, we don’t have a way to fix the causes yet and we dont know all of them.

    *I am a cell bio PhD but not an immunology specialist.



  • At 22 I didn’t want kids. At 32 I have a kid without regrets. Prior to getting a long-term partner with the same mindset I think it is a bit much unless something or someone has scared you about “baby trapping”.

    Vasectomy reversal can usually be done but isn’t always effective.

    E:just saw you have a partner in agreement, in which case yeah go for it. Separate concern about how a 17y and 20y started dating but that’s not super relevant unless she’s pushing for this not just supporting the decision.



  • Yes, billionaires should not exist.

    Can we also agree that school should be free and kids should be fed? Can we agree that roads (and rails) should be made and kept safe? Can we agree that our food should be safe to eat and not full of chalk or worse? Etc etc the most practical way to do those things is for everyone to chip in aka taxes.

    One of the biggest problems in America is that since Reagan we’ve stopped truly taxing the rich and with that they’ve bought the government or enough of it to write the rules. Removal of the fairness doctrine, the repeal of glass-steagal, and citizens united are three big ones that come to mind. Where one-side can push their view without pushback or seeing the other side the idea of compromise goes out the window. That random opinions started getting treated same as facts is another thing. That companies could do stock buybacks and effectively manipulate their stock prices and C-suite/board pay meaning they can make money even without actual growth. And of course CU where money became speech and companies gained the benefits of being “people” without any of the detriments.





  • A lot of scientists are not great communicators. I am much better over text than I am in person… I never shoo anyone away in person but I also understand that in social settings most people only ask what I do out of courtesy rather than genuine interest.

    People enjoy the way certain people share their passion. This is a bit overdone for gaming channels focused on kids e.g. pewdiepie but there’s also the dude building a hut with Neolithic tools, or tasting rations, trying new foods, or just reacting to fried rice (uncle roger), gardening, or powerwashing. Nilered shares his passion for chemistry in a way a lot of people enjoy but for better or worse I don’t think it is about understanding Nature as much as it is connecting with a fellow human.

    PhDs are philosophy degrees because whether on purpose or not theses are filled with the personal philosophy of the writer wrapped in the paper of whatever research.



  • Communication only needs the brain nowadays, neuralink is shit but there are options for similar brain-machine interface that are workable for paralyzed people.

    Survival is harder. Ecmo, parenteral nutrition, and dialysis are organ supplements not replacements. Lacking lungs, GI, or kidneys will kill you. Dialysis supplements kidney function. Ecmo supplements lungs that are reduced capability. Parenteral nutrition supplements reduced GI function. There are mechanical hearts/assitive devices one dude had a mech heart one for years but you still need blood pumping. The liver has no assitive device you die in 24h without.